How Do Painkillers Reduce Pain in the Body?

The person uses a painkiller to reduce the pain due to any issues, for example, fever. Like all medicines, painkillers are allowed to be taken for the shortest period possible. Sometimes patients are recommended on a long-term basis to take medicine according to the painful conditions.

In various brand names, many pain relievers are available in the market. Paracetamol is one of the medicines prescribed if your pain is not too severe, and you do not have inflammation. It is used to treat pain and to lower a high temperature.

Another example is aspirin or also known as acetylsalicylic acid. This nonsteroidal anti-inflammatory drug abbreviated as NSAID is powerful in treating body pain, high fever, & inflammation in the body. It helps in relieving headache, swelling, and also reducing fever. This painkiller is the first discovered among the category.

Mechanism of action

Pain relievers reduce the prostaglandins (a chemical released when there is inflammation and cause pain and fever). NSAIDs inhibit the enzyme that makes prostaglandins, which as a result can lower the concentrations of prostaglandins. Due to this activity, conditions like fever, pain, and inflammation are reduced.

Through the blocking of prostaglandins, clotting of blood and the function of platelets is also reduced. Therefore, aspirin hinders platelets’ role differently from other NSAIDs. With this medicine, cardiac arrest and cerebrovascular accidents are prevented.

Mention the uses of Aspirin.

  • Aspirin helps to reduce mild and moderate pain as well as swelling.
  • It helps in reducing the sprains and strains.
  • The risk of cardiovascular events is minimized by taking a lower dose of aspirin daily
  • The person who has undergone angioplasty or coronary bypass surgery can be used.
  • Helpful for people having rheumatic conditions, including rheumatoid arthritis, and other inflammatory joint conditions
  • Reduces inflammation around the heart, known as pericarditis
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Risk and precautions

There are many risks associated with the intake of these types of painkillers. So this should be taken if and only if the doctor recommends it. The conditions such as

  • Haemophilia (a bleeding disorder)
  • uncontrolled high blood pressure
  • asthma
  • peptic or stomach ulcers
  • liver or kidney disease

If present, they should be cautious about taking aspirin.

Side effects

Most of the patients recovered from aspirin uses while other NSAIDs with few possible side effects. These side effects can be due to the dose taken by a patient. Hence, we would advise using the lowest adequate amount to minimize side effects. The gastrointestinal system is affected by the usage of aspirin. Gastrointestinal side effects are ulcerations, abdominal burning, pain, and cramping.

  • A person suffering from peptic ulcer disease or possible poor kidney function should avoid having the painkiller.
  • It can cause asthma.
  • The intake of painkillers can increase the level of uric acid in the blood and should be avoided for patients with hyperuricemia and gout.
  • People who are pregnant or breastfeeding may take low-dose


The doctor’s prescribed medicines to prevent a patient from pain are known to be a painkiller. Non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol, and opioids are the three main types of pain reliever: Numerous painkillers are available, and they all come in various brand names. It works by blocking (inhibiting) the effect of chemicals (enzymes) called cyclo-oxygenase (COX) enzymes.

Sahar Rashid

I am a professional writer and a blogger who writes for different news sites and private blogs. I am writing content on Help4Flash, OftenIt, The Daily News-Times, and many other websites.

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